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Volume 3 | Issue 2 | Year 2024 | Article Id: DST-V3I2P102 DOI: https://doi.org/10.59232/DST-V3I2P102
Modelling the Re-Growth of Beta Cells in Autoimmune Diabetes
Okorie, Charity Ebelechukwu, Ogwumu, David Onah, Nwaokolo Martin Afam
| Received | Revised | Accepted | Published |
|---|---|---|---|
| 11 Apr 2024 | 07 May 2024 | 30 May 2024 | 12 Jun 2024 |
Citation
Okorie, Charity Ebelechukwu, Ogwumu, David Onah, Nwaokolo Martin Afam. “Modelling the Re-Growth of Beta Cells in Autoimmune Diabetes.” DS Journal of Digital Science and Technology, vol. 3, no. 2, pp. 9-16, 2024.
Abstract
Type 1 diabetes is a type of disease that occurs when the beta cells that produce insulin are killed by the T cells. Diabetes has been a serious menace in the whole world. It has killed and deformed many people all over the world. Science has made it possible that there are a lot of varieties of drugs for the treatment of diabetes. Despite all these, many people still have diabetes. Many are finding it difficult to manage their diabetes. Despite the access diabetes has gained in technology which makes instruments for testing diabetes available, yet many people do not carry out this test to ascertain their status. Also, those who have access to the equipment are not even kin for the treatment of diabetes, which has contributed to some complications. In this research work, we modified a model proposed by Mahaffy and Edelstein Keshet (2007). In their model, we observed that they did not consider re-growth of dead beta cells. In our model, we introduce a parameter (g) (which will take care of the dead beta cells by way of re-growth to prevent diabetes from getting to the stage of complication. We validated our model by carrying out simulations with the parameter (g). The results obtained showed that the moment the re-growth parameter is introduced, Beta cells, which have a value of 0.00 at the initial time, begin to increase to 4.89, and the T cells decrease to 3.12 at 20 % of the re-growing parameter. At 50%, beta cells increased to 10.3 while T cells decreased to 3.08. At 70% of the regenerating parameter, beta cells increased to 16.16 while T cells decreased to 3.08. At 90%, beta cells increased to 25.98, and T cells decreased to 2.98. This study shows that the introduction of the re-growth parameter creates hope for diabetic patients.
Keywords
Re-growth parameter, Diabetic patients, Type 1 diabetes, Simulation, Insulin
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